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    SF
    San Francisco 49ers49ersSF
    4-0, 1-0 Away
    SEA
    Seattle SeahawksSeahawksSEA
    3-1, 2-0 Home

    San Francisco 49ers @ Seattle Seahawks

    • Gamecast
    • Preview
    • Odds
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    Game Odds
    Odds by

    2026-10-11T20:25ZOpenSpreadTotalML
    San Francisco 49ersSan Francisco 49ersSF
    (4-0)
    (4-0)
    o46.5
    -110
    +3
    -110
    o45.5
    -115
    +136
    Seattle SeahawksSeattle SeahawksSEA
    (3-1)
    (3-1)
    -3.5
    -110
    -3
    -110
    u45.5
    -105
    -162
    See More Odds

    Recent Schedule

    DATEOPPRESULTSPREADTOTAL
    10/04vsDENW24-14-348.5
    9/27vsARIW36-30-7.548.5
    9/20vsMIAW35-13-12.544.5
    9/10@LARW27-7+3.547.5
    8/27@LVW18-12+3.536.5

    Matchup Predictor

    San Francisco 49ers
    Seattle Seahawks
    55.7
    %

    SF

    44.0
    %

    SEA

    According to ESPN Analytics

    Betting 101

    The Beginner's Guide to BettingReady to enter the world of sports betting? Here's everything you need to know to get started.
    Emanuel Wilson
    SEA RB
    Christian McCaffrey
    SF RB
    Jaxon Smith-Njigba
    SEA WR
    Mike Evans
    SF WR
    George Kittle
    SF TE
    Deebo Samuel Sr.
    SF WR
    AJ Barner
    SEA TE
    George Holani
    SEA RB
    FIRST TD
    Anytime TD
    2+ TDs
    +500
    -120
    +500
    +500
    -140
    +400
    +600
    -105
    +650
    +1200
    +195
    +1700
    +1300
    +185
    +1400
    +1300
    +220
    +1800
    +1600
    +310
    +3000
    +1600
    +300
    +3000
    See More Odds
    Brock Purdy
    SF QB
    24+
    26+
    28+
    30+
    32+
    33+
    -109
    34+
    36+
    38+
    40+
    42+
    44+
    46+
    Sam Darnold
    SEA QB
    22+
    24+
    26+
    28+
    30+
    31+
    32+
    +106
    34+
    36+
    38+
    40+
    42+
    44+
    See More Odds
    Brock Purdy
    SF QB
    Sam Darnold
    SEA QB
    o226.5
    -112
    u226.5
    -112
    o225.5
    -111
    u225.5
    -113
    See More Odds
    Emanuel Wilson
    SEA RB
    Christian McCaffrey
    SF RB
    Brock Purdy
    SF QB
    George Holani
    SEA RB
    o63.5
    -112
    u63.5
    -112
    o53.5
    -114
    u53.5
    -110
    o22.5
    -107
    u22.5
    -117
    o19.5
    -113
    u19.5
    -111
    See More Odds
    Jaxon Smith-Njigba
    SEA WR
    George Kittle
    SF TE
    Mike Evans
    SF WR
    Christian McCaffrey
    SF RB
    Deebo Samuel Sr.
    SF WR
    Cooper Kupp
    SEA WR
    o92.5
    -113
    u92.5
    -111
    o52.5
    -114
    u52.5
    -110
    o48.5
    -110
    u48.5
    -114
    o36.5
    -111
    u36.5
    -113
    o35.5
    -111
    u35.5
    -113
    o24.5
    -109
    u24.5
    -115
    See More Odds
    Seattle Seahawks
    3-1
    San Francisco 49ers
    4-0
    o14.5
    -900
    u14.5
    +600
    o11.5
    -900
    u11.5
    +600
    See More Odds

    Injury Report

    San Francisco 49ers
    NameStatus
    Mike EvansM. EvansWR
    QuestionableRibs
    Upton StoutU. StoutCB
    QuestionableShoulder - AC Joint
    James Thompson Jr.J. Thompson Jr.DT
    DoubtfulAnkle
    Nick BosaN. BosaDE
    DoubtfulCalf
    Christian KirkC. KirkWR
    IR-RCalf
    Seattle Seahawks
    NameStatus
    George HolaniG. HolaniRB
    QuestionableRibs
    Julian NealJ. NealCB
    QuestionableHamstring
    Nehemiah PritchettN. PritchettCB
    QuestionableAnkle
    Irv CharlesI. CharlesWR
    IR-RUndisclosed
    Chazz SurrattC. SurrattLB
    QuestionableCalf
    Full Injury Report

    Super Bowl Winner

    TEAMODDS
    LARLAR+650
    BUFBUF+750
    BALBAL+850
    SFSF+850
    KCKC+900
    SEASEA+950
    JAXJAX+1500
    CHICHI+1600
    TEAMODDS
    CINCIN+1900
    DENDEN+2000
    DALDAL+2200
    MINMIN+2200
    NENE+2500
    DETDET+2800
    PHIPHI+3000
    HOUHOU+4500
    See More NFL Futures
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