Adley Rutschman hit two of Baltimore's six homers and drove in six runs as the Orioles routed the slumping Boston Red Sox 10-3 on Friday night.
Baltimore hit five of its homers off Boston starter Brayan Bello.
Coby Mayo homered for a career-best third straight game. Gunnar Henderson and Dylan Beavers also went deep during a three-homer, four-run first inning for the Orioles.
Samuel Basallo added a third-inning solo shot as part of 13 Baltimore hits in 3⅓ innings against Bello (1-3), who had never allowed more than three homers or 10 hits in 104 previous MLB outings.
Basallo and Taylor Ward each had four of the Orioles' 20 total hits to back Brandon Young (2-0), who worked 5⅔ innings after being recalled Thursday from Triple-A Norfolk to replace injured right-hander Dean Kremer.
Rutschman has homered in consecutive games since returning from a minimum-length stint on the 10-day injured list with left ankle inflammation. He finished 3-for-5 with two runs to go with his 6 RBIs in his fourth career multihomer game. He has three homers and 8 RBIs in two games since returning from the IL, according to ESPN Research.
Bello's eight earned runs allowed lifted his ERA to 9.00 (22 earned runs in 22 innings pitched) in Boston's fourth straight loss and the team's sixth loss in seven games.
Wilyer Abreu homered for the Red Sox, Marcelo Mayer doubled in a run and Ceddanne Rafaela added an RBI groundout.
After Henderson's leadoff shot, Rutschman sent a 2-2 sinker high in the strike zone into the seats right-center to make it 3-0.
His run-producing fielder's choice in the second stretched it to 5-1. In the fourth, he hooked Bello's 2-1 cutter inside the right-field foul pole to extend the lead to 8-1. He finished his day with an RBI single in the seventh inning.
Information from The Associated Press was used in this report.