Michael van Gerwen will miss Thursday night's Premier League round in Glasgow due to illness.
The Dutchman, who has won the tournament a record seven times, has been ruled out with a "medical issue."
A PDC statement read: "Michael van Gerwen has withdrawn from Thursday's BetMGM Premier League action in Glasgow due to illness.
"The seven-time Premier League champion has been ruled out of night three at the OVO Hydro tonight due to a medical issue."
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Van Gerwen, who sits at the top of the table after the opening two nights, was due to meet Luke Littler in a blockbuster quarterfinal.
But the world champion will get a bye to the semifinal where he will meet either Jonny Clayton or Gerwyn Price.
The PDC confirmed that as well as a bye, Littler subsequently takes two league points and +1 leg difference. Van Gerwen receives no league points and -6 leg difference.
Van Gerwen's compatriot Vincent van der Voort revealed on the Darts Draait Door podcast that his friend has "picked something up" and is on antibiotics.
Information from ESPN's Tom Chambers contributed to this story.