MLB wild-card round odds: The favorites for every series

Michael King of the San Diego Padres took a no-hitter into the seventh inning of Game 1 against the Cubs. Orlando Ramirez/Getty Images

The MLB wild-card round continues Wednesday with a quartet of Game 2s.

Teams in this round play a best-of-three series, with all three games taking place in the home stadium of the better-seeded team. Those series are Chicago White Sox at Houston Astros, Boston Red Sox at New York Yankees, Philadelphia Phillies at Atlanta Braves and Chicago Cubs at San Diego Padres.

The two division winners with the best records in each league (Tampa Bay Rays, Cleveland Guardians, Milwaukee Brewers, Los Angeles Dodgers) all get a chance to rest their regulars and set up their rotations for the next round, where they'll square off with the wild-card winners beginning Saturday.

For more on the MLB playoffs, check out each team's odds to win the World Series.

Odds by DraftKings and are accurate as of time of publication.


Chicago White Sox at Houston Astros
All games at Daikin Park


To win series: White Sox -245, Astros +195

Game 1: White Sox 6, Astros 3

Game 2: Wednesday, 5 p.m. ET

Moneyline: Astros −147, White Sox +121
Run Line: Astros (-1.5) +157, White Sox (+1.5) -191
Over/Under 7.5 runs: O -110/U -110

*Game 3: Thursday, 5 p.m. ET (if necessary)


Boston Red Sox at New York Yankees
All games at Yankee Stadium


To win series: Yankees −380, Red Sox +300

Game 1: Yankees 9, Red Sox 0

play
0:56
Ben Rice powers Yankees with 2 HRs, 6 RBIs in Game 1

Game 2: Wednesday, 8 p.m. ET

Moneyline: Yankees −141, Red Sox +117
Run Line: Yankees (-1.5) +163, Red Sox (+1.5) -199
Over/Under 6.5 runs: O -117/U -102

*Game 3: Thursday, Oct. 1, 8 p.m. ET (if necessary)


Philadelphia Phillies at Atlanta Braves
All games at Truist Park


To win series: Braves −310, Phillies +240

Game 1: Braves 5, Phillies 3

play
0:55
Austin Riley's go-ahead, 3-run HR sends Braves past Phillies in Game 1

Game 2: Wednesday, 2 p.m. ET

Moneyline: Phillies +-114, Braves −106
Run Line: Phillies (-1.5) +153, Braves (+1.5) -186
Over/Under 7.0 runs: O -114/U -106

*Game 3: Thursday, 2 p.m. ET (if necessary)


Chicago Cubs at San Diego Padres
All games at Petco Park


To win series: Padres −450, Cubs +340

Game 1: Padres 8, Cubs 0

Game 2: Wednesday, 10 p.m. ET

Moneyline: Padres −145, Cubs +120
Run Line: Padres (-1.5) +152, Cubs (+1.5) -185
Over/Under 7.0 runs: O -125/U +104

*Game 3: Thursday, 10 p.m. ET (if necessary)